Not likely, but it sure would be something to talk about!
"The Attorney-General's kind remarks are noted and appreciated. I've spoken to Ed Burns and we are prepared to go to work on season six of The Wire if the Department of Justice is equally ready to reconsider and address its continuing prosecution of our misguided, destructive and dehumanising drug prohibition."
The Wire was fantastic. I was recently re-watching the whole series, but one of my season five discs isn't playing properly. Anyway, I would be cautiously enthusiastic for a season six, but if it isn't going to be better than season five, it would be better to leave it alone and start a new series.